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Immunological tolerance is maintained by self-reactive CD8 T cells

GSE327753 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/13 Platform GPL24247
Summary
CD8 T cells play a critical role in immune tolerance maintenance after immune activation. They have recently been reported to target activated CD4 T cells in an MHC-Ia–restricted manner. However, the specific peptides and the corresponding reactive CD8 TCRs responsible for this targeting process remain unknown. In this study, we identified the self-peptides on activated CD4 T cells, cloned the corresponding CD8 TCRs, and validated the in vitro and in vivo immunosuppressive function of CD8 T cells carrying these self-reactive TCRs. The therapeutic potential of peptide vaccination and self-reactive CD8 T cells was confirmed in a mouse model of experimental autoimmune encephalitis (EAE). This study consequently redefines the nature of CD8 regulatory T (Treg) cells as self-reactive CD8 T cells.
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Direct links to NCBI, no account and no request form: the whole study as GSE327753_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1452731 and SRA study SRP691280. Searching any of these in the dataset finder brings you back here.

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