Effect of MSCs or tpMSCs on gene expression in hypoxia/LPS-induced dilated acute lung injury
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × Control vs 3 × ALI vs 3 × MSC vs 3 × tpMSCGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE327991_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1453467 and SRA study SRP691764. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9670074 Control_1 Control
- GSM9670075 Control_2 Control
- GSM9670076 Control_3 Control
- GSM9670077 ALI_1 ALI
- GSM9670078 ALI_2 ALI
- GSM9670079 ALI_3 ALI
- GSM9670080 MSC_1 MSC
- GSM9670081 MSC_2 MSC
- GSM9670082 MSC_3 MSC
- GSM9670083 tpMSC_1 tpMSC
- GSM9670084 tpMSC_2 tpMSC
- GSM9670085 tpMSC_3 tpMSC
- GSE276682 Single-cell transcriptome analysis revealed cellular reprogramming following Tetramethylpyrazine treatment in LPS-induced acute lung injury 12 samples shares lps-induced, injury, acute, lung
- GSE325662 Gene expression profiling of lung tissue from LPS-induced acute lung injury mice treated with Renshen Baidu Powder 9 samples shares lps-induced, injury, acute, lung
- GSE264278 TIme-cource single-cell RNA-seq analysis of bleomycin and LPS-induced lung injury and fibrosis 18 samples shares lps-induced, injury, lung
- GSE202753 DsbA-L deficiency attenuates LPS-induced acute kidney injury via NF-κB/AP-1 regulation of macrophage polarization 13 samples shares lps-induced, injury, acute
- GSE315731 Hepatic Hypoxia-Inducible Factor 1α Mediates Ferroptosis via Transferrin Receptor 1 in Acute Liver Injury 12 samples shares hypoxia, injury, acute
- GSE251991 Hypoxia Sensing in Resident Cardiac Macrophages Regulates Monocyte Fate Specification following Ischemic Heart Injury 16 samples shares hypoxia, injury
- GSE272157 RNA sequencing of lung tissue from wildtype and hypoxia-induced pulmonary hypertension/hypoxia-induced pulmonary hypertension mice under aerobic exercise conditions 10 samples shares hypoxia, lung
- GSE244864 Gene expression profile at single cell level of whole lung cells from C57BL/6J mice or global STING knock-out mice (STING-/-), exposed to either room air or chronic hypoxia (4-week 10% oxygen). 8 samples shares hypoxia, lung
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.