← BioTransfer GEO Dataset Finder
GEO series

Effects of LXR intervention on transcriptome expression in the injury area of mice with spinal cord injury

GSE328020 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/19 Platform GPL28330
Summary
Spinal cord injury (SCI) induces extensive myelin breakdown and releases large amounts of lipids into the lesion microenvironment, driving macrophage-to-foam cell transformation and sustaining chronic inflammation. Reverse cholesterol transport (RCT) is the major pathway responsible for lipid efflux, yet its functional dynamics and regulatory imbalance after SCI remain poorly understood. This study aims to characterize the temporal expression patterns and cellular localization of key RCT components (ABCA1, ABCG1, and APOE) after SCI, and to evaluate whether activation of the LXR/RXR pathway by the agonist AZ876 can modulate RCT function, reduce foam cell accumulation, and improve neurological recovery.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE328020_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1453526 and SRA study SRP691816. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.