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Lenvatinib-treated Tregs exhibit superior anti-inflammation effect in autoimmune diseases

GSE328467 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/07/30 Platform GPL24247
Summary
Adoptive transfer of regulatory T cells (Tregs) holds promise for treating autoimmune diseases (AIDs) such as inflammatory bowel disease (IBD), psoriasis, and rosacea, but its clinical application is hampered by the difficulty of generating sufficient stable and functional Tregs. Here, we identified a novel immunomodulatory function of the multi-kinase inhibitor lenvatinib (Lenv) in specifically promoting Treg differentiation without affecting other T helper cell subsets. Mechanistically, Lenv inhibited VEGFR/AKT signaling and activated Foxo1, thereby enhancing Foxp3 expression. Adoptive transfer of Lenv-treated Tregs (Lenv-Tregs) in murine models of IBD, psoriasis, and rosacea achieved superior alleviation of clinical symptoms and inflammation compared with vehicle-treated Tregs (Ctrl-Tregs). Our findings uncover a novel role for Lenv in Treg differentiation and provide a robust strategy to generate a considerable number of highly potent immunosuppressive Tregs for cell-based therapy against AIDs.
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Also filed as BioProject PRJNA1455486 and SRA study SRP693125. Searching any of these in the dataset finder brings you back here.

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