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Age-dependent CNS responses to Powassan virus infection revealed by single-cell RNA sequencing

GSE329199 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/28 Platform GPL34290
Summary
Powassan virus (POWV) causes highly lethal encephalitis in the elderly and long-term cognitive deficits in survivors. Mirroring human severity, POWV LI9 directs age-dependent lethality in B6 mice resulting in spongiform encephalitis, gliosis and inflammatory cytokine/chemokine responses in the CNS. Here we analyzed POWV LI9 infected brains from 10 (young) and 50 week old (aged) B6 mice using 10x Genomics scRNA-seq to define CNS responses that direct age-dependent lethality.
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Direct links to NCBI, no account and no request form: the whole study as GSE329199_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1458141 and SRA study SRP695269. Searching any of these in the dataset finder brings you back here.

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