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Lamins gate nuclear and chromatin structures for cardiomyocyte maturation genes. (CUT&RUN)

GSE330102 Mus musculus (mouse) ChIP-seq / ATAC-seq (genome binding and open chromatin) 18 samples Submitted 2026/08/05 Platform GPL32159
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 18 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Mus musculus (mouse)
Samples
18 samples: 8 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Lamins gate nuclear and chromatin structures for cardiomyocyte maturation genesbioRxiv : the preprint server for biology · 2026
Summary (written by the submitters)
The nuclear lamina contains intermediate filaments, called lamins, which function to maintain nuclear integrity and organize the Lamina-Associated chromatin Domains (LADs). Despite near ubiquitous expression, lamins show cell-type-specific functions. In the heart, they support epicardial cell migration, cardiomyocyte nuclear integrity and maturation.
Read the full summary ↓
How these functions are integrated with different gene expression programs in these cells during heart development is unknown. We show that cardiomyocytes require lamin-A and -B1 for perinatal mouse survival. Importantly, lamin-B1 facilitates timely cardiomyocyte maturation by maintaining LADs and chromosome territories. By examining changes in cardiomyocyte gene expression and 3D genome organization upon lamin-B1 deletion, we show lamin-B1 maintains chromatin neighborhoods, which can in turn support transcription factors that regulate genes involved in cardiomyocyte structural maturation and gradual cessation of cell division. We propose a genomic logic by which the widely expressed lamins collaborate with transcription factors to specifically promote cardiomyocyte maturation and cell cycle exit during development.
Published in
Lamins gate nuclear and chromatin structures for cardiomyocyte maturation genes
Bossone KA, Zheng X, Kristiani L et al. · bioRxiv : the preprint server for biology 2026 · PMID 42239077 · doi:10.64898/2026.05.20.726565
This dataset
Open GSE330102 in finder → Find more mouse ChIP / ATAC / CUT&Tag datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE330102_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1462735 and SRA study SRP698020. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 42239077) ↗
Study design
8 conditions, mostly in duplicate
WT, P0.5 Heart, IgG CUT&RUN, ×4 WT, P0.5 Heart, H3K9me2 CUT&RUN, ×2 WT, P0.5 Heart, H3K9me3 CUT&RUN, ×2 WT, P0.5 Heart, H3K27ac CUT&RUN, ×2 Nkx2-5Cre;Lmnb1Flox/+, P0.5 Heart, Lamin-A CU… ×2 Nkx2-5Cre;Lmnb1Flox/-, P0.5 Heart, Lamin-A CU… ×2 Nkx2-5Cre;Lmnb1Flox/+, P0.5 Heart, IgG CUT&RU… ×2 Nkx2-5Cre;Lmnb1Flox/-, P0.5 Heart, IgG CUT&RU… ×2

Supports a between-group comparison across 18 samples.

How we read this: 8 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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