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Effects of T cell–specific IL-21 isoform expression on gene expression in mammary epithelial cells.

GSE331007 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/18 Platform GPL24247
Summary
Interleukin-21 (IL-21) is a pleiotropic cytokine produced by CD4⁺ T cells that critically regulates the differentiation and functions of various adaptive and innate immune cells. In this study, to investigate the chronic effects of IL-21 on gene expression in mammary epithelial cells (MECs), MECs were isolated from 10-week-old transgenic mice expressing a membrane-bound IL-21 isoform specifically in T cells (IL-21isoTg) and subjected to RNA sequencing analysis, followed by comparison with wild-type controls. IL-21isoTg MECs showed marked upregulation of genes associated with mammary gland development and lactation and Spp1.
Published in
IL-21 isoform transgenic mice spontaneously develop mammary tumors: possible involvement of IL-21-induced osteopontin expression in tumorigenesis
Yamaguchi R, Araki A, Takeda Y et al. · Frontiers in immunology 2026 · PMID 42375343 · doi:10.3389/fimmu.2026.1834095
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Also filed as BioProject PRJNA1466503 and SRA study SRP700660. Searching any of these in the dataset finder brings you back here.

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