← BioTransfer GEO Dataset Finder
GEO series

Dysregulated calcium underlies hyposalivation and microbial dysbiosis in Down syndrome

GSE331212 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/05/29 Platform GPL34290
Summary
Oral diseases have a lifelong impact on human health and quality of life. Down syndrome (DS) individuals contend with decreased saliva production and periodontal disease for unknown reasons. We investigated the molecular mechanisms of hyposalivation in a DS mouse model (Dp16 mice) and identified decreased Ca2+ uptake in salivary glands essential for saliva fluid secretion. Human iPSC from DS individuals also showed decreased Ca2+ uptake. Decreased saliva in Dp16 mice altered the oral and gut microbiome enriched in succinate-associate microbes. Metabolomic analysis confirmed elevated succinate levels, a signaling molecule linked to periodontal disease. Because Ca2+ dysregulation and hyposalivation are features of Sjogren’s disease, we addressed if DS individuals might be at greater risk of developing Sjogren’s by treating Dp16 mice with DMXAA. Treated Dp16 mice exhibited signs of Sjogren’s. Using the therapeutic agent pilocarpine prescribed in the management of Sjogren’s we enhanced salivation and decreased inflammation.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE331212_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1467504 and SRA study SRP701552. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.