Retina-specific glucocorticoid receptor deletion disrupts rhythmic gene expression in the mouse retina under light-dark conditions
RNA-seq (gene expression) · mouse · 8 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 8 samples: 4 × Mice, WT, ZT vs 4 × Mice, cNr3c1, ZTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE337903_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1491476 and SRA study SRP716118. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 2 replicated groups read from 8 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9862545 Mice, WT, ZT3 Mice, WT, ZT
- GSM9862546 Mice, WT, ZT9 Mice, WT, ZT
- GSM9862547 Mice, WT, ZT15 Mice, WT, ZT
- GSM9862548 Mice, WT, ZT21 Mice, WT, ZT
- GSM9862549 Mice, cNr3c1, ZT3 Mice, cNr3c1, ZT
- GSM9862550 Mice, cNr3c1, ZT9 Mice, cNr3c1, ZT
- GSM9862551 Mice, cNr3c1, ZT15 Mice, cNr3c1, ZT
- GSM9862552 Mice, cNr3c1, ZT21 Mice, cNr3c1, ZT
- GSE338377 Retina-specific glucocorticoid receptor deletion disrupts rhythmic gene expression in the mouse retina under constant dark conditions. 12 samples shares retina-specific, glucocorticoid, conditions, receptor, deletion, disrupts, rhythmic
- GSE248864 Hepatic Glucocorticoid Receptor (GR) drives the diurnal adaptation to Caloric Restriction 90 samples shares glucocorticoid, receptor
- GSE306262 Astrocyte glucocorticoid receptor signaling restricts neuronal plasticity [RNA-seq] 40 samples shares glucocorticoid, receptor
- GSE296401 Interleukin-23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity II 38 samples shares glucocorticoid, receptor
- GSE282871 The multimerization pathway of the glucocorticoid receptor 34 samples shares glucocorticoid, receptor
- GSE287351 Bile acids bind to exposed cavities in the glucocorticoid receptor 24 samples shares glucocorticoid, receptor
- GSE268268 JAK/STAT inhibition restores disease tolerance in malaria-infected glucocorticoid receptor knockout mice. 18 samples shares glucocorticoid, receptor
- GSE286363 The Role of Sphingosine 1 Phosphate Receptor 2 Signaling in Chronic Glucocorticoid Exposure Induced Hepatic Steatosis and Hypertriglyceridemia 12 samples shares glucocorticoid, receptor
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.