Hepatic Glucocorticoid Receptor (GR) drives the diurnal adaptation to Caloric Restriction
RNA-seq (gene expression) · mouse · 90 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 90 samples: 28 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Hepatic metabolic reprogramming in male mice during short-term caloric restriction involves enhanced glucocorticoid rhythmsNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE248864_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1046135 and SRA study SRP474723. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 90 samples.
How we read this: 28 replicated groups read from 90 sample titles; they account for 90 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7921413 NRF_ZT0_WT_rep1 NRF_ZT0_WT
- GSM7921414 NRF_ZT0_WT_rep2 NRF_ZT0_WT
- GSM7921415 NRF_ZT0_WT_rep3 NRF_ZT0_WT
- GSM7921416 NRF_ZT0_GRLKO_rep1 NRF_ZT0_GRLKO
- GSM7921417 NRF_ZT0_GRLKO_rep2 NRF_ZT0_GRLKO
- GSM7921418 NRF_ZT0_GRLKO_rep3 NRF_ZT0_GRLKO
- GSM7921419 NRF_ZT4_WT_rep1 NRF_ZT4_WT
- GSM7921420 NRF_ZT4_WT_rep2 NRF_ZT4_WT
- GSM7921421 NRF_ZT4_WT_rep3 NRF_ZT4_WT
- GSM7921422 NRF_ZT4_GRLKO_rep1 NRF_ZT4_GRLKO
- GSM7921423 NRF_ZT4_GRLKO_rep2 NRF_ZT4_GRLKO
- GSM7921424 NRF_ZT4_GRLKO_rep3 NRF_ZT4_GRLKO
- GSM7921425 NRF_ZT8_WT_rep1 NRF_ZT8_WT
- GSM7921426 NRF_ZT8_WT_rep2 NRF_ZT8_WT
- GSM7921427 NRF_ZT8_WT_rep3 NRF_ZT8_WT
- GSM7921428 NRF_ZT8_WT_rep4 NRF_ZT8_WT
- GSM7921429 NRF_ZT8_GRLKO_rep1 NRF_ZT8_GRLKO
- GSM7921430 NRF_ZT8_GRLKO_rep2 NRF_ZT8_GRLKO
- GSM7921431 NRF_ZT8_GRLKO_rep3 NRF_ZT8_GRLKO
- GSM7921432 NRF_ZT8_GRLKO_rep4 NRF_ZT8_GRLKO
- GSM7921433 NRF_ZT12_WT_rep1 NRF_ZT12_WT
- GSM7921434 NRF_ZT12_WT_rep2 NRF_ZT12_WT
- GSM7921435 NRF_ZT12_WT_rep3 NRF_ZT12_WT
- GSM7921436 NRF_ZT12_WT_rep4 NRF_ZT12_WT
- GSM7921437 NRF_ZT12_GRLKO_rep1 NRF_ZT12_GRLKO
- GSM7921438 NRF_ZT12_GRLKO_rep2 NRF_ZT12_GRLKO
- GSM7921439 NRF_ZT12_GRLKO_rep3 NRF_ZT12_GRLKO
- GSM7921440 NRF_ZT12_GRLKO_rep4 NRF_ZT12_GRLKO
- GSM7921441 NRF_ZT16_WT_rep1 NRF_ZT16_WT
- GSM7921442 NRF_ZT16_WT_rep2 NRF_ZT16_WT
- GSM7921443 NRF_ZT16_WT_rep3 NRF_ZT16_WT
- GSM7921444 NRF_ZT16_WT_rep4 NRF_ZT16_WT
- GSM7921445 NRF_ZT16_GRLKO_rep1 NRF_ZT16_GRLKO
- GSM7921446 NRF_ZT16_GRLKO_rep2 NRF_ZT16_GRLKO
- GSM7921447 NRF_ZT16_GRLKO_rep3 NRF_ZT16_GRLKO
- GSM7921448 NRF_ZT20_WT_rep1 NRF_ZT20_WT
- GSM7921449 NRF_ZT20_WT_rep2 NRF_ZT20_WT
- GSM7921450 NRF_ZT20_WT_rep3 NRF_ZT20_WT
- GSM7921451 NRF_ZT20_WT_rep4 NRF_ZT20_WT
- GSM7921452 NRF_ZT20_GRLKO_rep1 NRF_ZT20_GRLKO
+ 50 more — browse all 90 samples with per-sample file links →
- GSE330380 The effects of adiponectin knockout on hepatic gene expression in male and female C57BL/6NCrl mice fed ad libitum or undergoing caloric restriction 22 samples shares restriction, hepatic, caloric
- GSE248866 The outcomes of caloric restriction are driven by enhanced glucocorticoid rhythms. 114 samples shares glucocorticoid, restriction, caloric
- GSE306262 Astrocyte glucocorticoid receptor signaling restricts neuronal plasticity [RNA-seq] 40 samples shares glucocorticoid, receptor
- GSE296874 RNA-Seq analysis of high-fiber diets and caloric restriction in mouse liver 36 samples shares restriction, caloric
- GSE274902 Mogat1 drives metabolic adaptations to evade immune surveillance 32 samples shares adaptation, drives
- GSE282595 Concerted Actions of FoxO1 and Pparα in hepatic gene expression and metabolic adaptation 24 samples shares adaptation, hepatic
- GSE319950 Erk3 deletion drives oxidative adaptations in skeletal muscle 18 samples shares adaptation, drives
- GSE314547 Estradiol disrupts constitutive androstane receptor (CAR)-mediated bile acid homeostasis in a murine model of intrahepatic cholestasis of pregnancy (ICP), and this effect is reversed by CAR ligands 16 samples shares receptor, hepatic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.