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Hepatic transcriptome profiling of wild-type mice treated with GalNAc-siRnf10

GSE337995 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/07/23 Platform GPL28330
Summary
This study aimed to investigate the hepatic transcriptomic effects of GalNAc-conjugated siRNA-mediated Rnf10 knockdown in vivo. Wild-type mice were maintained on a normal chow diet and treated with GalNAc-siNC or GalNAc-siRnf10 at the indicated time points. Liver tissues were collected at the end of the experiment and subjected to bulk RNA sequencing. Differential gene expression analysis was performed to identify genes and pathways altered by GalNAc-siRnf10 treatment. Seed match enrichment analysis was further used to evaluate potential off-target effects associated with the siRnf10 guide strand.
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Direct links to NCBI, no account and no request form: the whole study as GSE337995_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1492057 and SRA study SRP716337. Searching any of these in the dataset finder brings you back here.

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