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Chip seq data of transcription factor ELF-1 in mouse BMDM derived macrophages.

GSE338150 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2026/07/09 Platform GPL24247
Summary
Acute kidney injury (AKI) is an unavoidable complication following renal transplantation and a critical determinant of patient prognosis. M1-polarized macrophages are known to exacerbate the progression of AKI. Preliminary clinical data reveal a positive correlation between the expression level of E74-like ETS transcription factor 1 (ELF-1) in macrophages from post-transplant patients and the levels of pro-inflammatory cytokines. However, the role of ELF-1 in M1 macrophage polarization and the pathogenesis of AKI remains unclear. In this study, we aim to investigate the role of ELF-1 in M1 macrophage polarization and AKI pathogenesis by employing ELF-1-deficient murine macrophages and performing ChIP-seq to identify downstream genes regulated by ELF-1.
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Direct links to NCBI, no account and no request form: the whole study as GSE338150_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1492625 and SRA study SRP716717. Searching any of these in the dataset finder brings you back here.

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