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Single-cell RNA sequencing of knee joint synovium from mice with collagen- and antibody-induced arthritis (C&AIA)

GSE341410 Mus musculus Expression profiling by high throughput sequencing 3 samples Submitted 2026/07/31 Platform GPL28330
Summary
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation, immune cell infiltration, and progressive joint destruction. Commonly used mouse models each carry practical constraints: collagen-induced arthritis (CIA) is largely restricted to the DBA/1 strain, whereas collagen antibody-induced arthritis (CAIA) is limited by antibody cost. To combine strain flexibility with a robust and reproducible effector phase, we established collagen- and antibody-induced arthritis (C&AIA) on the C57BL/6 background. To characterize the synovial cellular landscape of this model, we performed droplet-based single-cell RNA sequencing on synovial tissue dissected from inflamed knee joints of arthritic C&AIA mice. This dataset resolves the immune and stromal compartments of the C&AIA synovium and enables cross-species comparison with human RA synovial single-cell data.
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Direct links to NCBI, no account and no request form: the whole study as GSE341410_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 3 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1502579 and SRA study SRP721477. Searching any of these in the dataset finder brings you back here.

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