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GPX3 suppresses lung adenocarcinoma progression through HSPB1 ubiquitination and Hippo pathway activation

GSE341979 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/07/30 Platform GPL34284
Summary
Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer; however, its prognosis remains poor, and the underlying molecular mechanisms have yet to be fully elucidated. In this study, a prognostic model was constructed based on manganese metabolism-related genes, which effectively stratifies LUAD patients with different prognoses and drug sensitivity. Mendelian randomization analysis identified glutathione peroxidase 3 (GPX3) as a key prognostic gene, which was downregulated in LUAD and significantly correlated with favorable outcomes.
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Direct links to NCBI, no account and no request form: the whole study as GSE341979_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1504946 and SRA study SRP722853. Searching any of these in the dataset finder brings you back here.

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