The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 15 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples
- Data you can get
- A processed expression table (series matrix) and the array files, from NCBI.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE36348_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA153305 and SRA study SRP011375. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 15 more — browse all 15 samples with per-sample file links →
- GSE268911 SMAD1/5-Mediated Recruitment of the Histone Demethylase KDM1A Controls Cell Fate Programs in Embryonic Stem Cells [ChIP-seq] 18 samples shares kdm1a, demethylase, histone
- GSE25911 Expression changes after loss of Dot1l in murine MLL-AF9 leukemia cells 26 samples shares mll-af9, leukemia
- GSE3722 MLL-AF9 transforms committed progenitors to leukemia stem cells by activation of a stem cell program (expt 2) 22 samples shares mll-af9, leukemia
- GSE263078 The histone demethylase KDM5C regulates IRF transcriptional programming impacting dendritic cell population heterogeneity and function 67 samples shares demethylase, histone
- GSE214682 The histone H3 lysine 36 demethylase KDM2A/FBXL11 is essential for germ cell development in male mice 56 samples shares demethylase, histone
- GSE262866 The histone demethylase KDM5C regulates IRF transcriptional programming impacting dendritic cell population heterogeneity and function (RNA-seq) 55 samples shares demethylase, histone
- GSE287065 Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants [Histone LCD] 48 samples shares demethylase, histone
- GSE196745 Changes in Ikaros binding and histone-modifications upon oncogenic β-catenin activation [ChIP-Seq] 30 samples shares oncogenic, histone
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.