GEO series

Gene expression profiling along the intestinal crypt axis.

GSE36497 Mus musculus Expression profiling by array 8 samples Submitted 2012/08/15 Platform GPL4134

Summary

The identification of Lgr5 as an intestinal stem cell marker has made it possible to isolate and study primary intestinal stem cells. Transcriptional differences between intestinal stem cells can be explored by the use of the Lgr5-eGFP-ires-CreERT2 knock-in mouse. In this mouse model GFP expression is driven from the Lgr5 locus, leading to highest GFP levels in the Lgr5 positive cells. Yet, due to the stability of the GFP protein, it is distributed upon cell division to the daughter cells. Here we arbitrarily sorted crypt cells based on GFP expression into five fractions. The fraction with the lowest GFP level is named 1+, the fraction with the highest level 5+.

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Direct links to NCBI, no account and no request form: the whole study as GSE36497_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA153541. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 22692129) ↗

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