Genome-wide DNA methylation profiling of human dorsolateral prefrontal cortex
DNA methylation · human · 24 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Homo sapiens (human)
- Samples
- 24 samples: 24 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE42590_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA182334 and SRA study SRP017339. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 24 sample titles: 24 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM1045530 2619_DLPFC_Control
- GSM1045531 3572_DLPFC_Control
- GSM1045532 3706_DLPFC_Control
- GSM1045533 3281_DLPFC_Control
- GSM1045534 3228_DLPFC_Control
- GSM1045535 1834_DLPFC_Control
- GSM1045536 2664_DLPFC_Control
- GSM1045537 3686_DLPFC_Control
- GSM1045538 2316_DLPFC_Control
- GSM1045539 2805_DLPFC_Control
- GSM1045540 3433_DLPFC_Control
- GSM1045541 3965_DLPFC_Control
- GSM1045542 3523_DLPFC_Control
- GSM1045543 3774_DLPFC_Control
- GSM1045544 2248_DLPFC_Control
- GSM1045545 3519_DLPFC_Control
- GSM1045546 3275_DLPFC_Control
- GSM1045547 3516_DLPFC_Control
- GSM1045548 4063_DLPFC_Control
- GSM1045549 3588_DLPFC_Control
- GSM1045550 2292_DLPFC_Control
- GSM1045551 3196_DLPFC_Control
- GSM1045552 3186_DLPFC_Control
- GSM1045553 3018_DLPFC_Control
- GSE298243 Single-Cell Profiling of DNA Methylation in Autism Spectrum Disorder Prefrontal Cortex Reveals Distinct Regulatory and Aging Signatures 49 samples shares methylation, prefrontal, cortex
- GSE328351 Bulk RNA-seq of dorsolateral prefrontal cortex tissue collected during deep brain stimulation neurosurgery in obsessive-compulsive disorder and neurological controls 10 samples shares dorsolateral, prefrontal, cortex
- GSE74193 Mapping DNA methylation across development, genotype, and schizophrenia in the human frontal cortex 675 samples shares methylation, cortex
- GSE33000 Gene expression profiles of human prefrontal cortex brain tissues 624 samples shares prefrontal, cortex
- GSE30272 Temporal Dynamics and Genetic Control of Transcription in the Human Prefrontal Cortex 269 samples shares prefrontal, cortex
- GSE23841 DNA methylation data from human liver, frontal cortex, spleen and colon 25 samples shares methylation, cortex
- GSE319444 DNA methylation stochasticity is linked to transcriptional variability and identifies convergent epigenetic disruption across genetically-defined subtypes of AML [PrimaryAML_WGBS] 20 samples shares methylation
- GSE271127 Substained DNA demethylation and discordant chromatin accessibility dynamics define enhancer regulation during neural progenitor cell differentiation [ATACme] 18 samples shares methylation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.