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Expression data from osteoblastic lineage cells isolated from normal and leukemic mice

GSE48438 Mus musculus Expression profiling by array 10 samples Submitted 2013/07/11 Platform GPL6246
Summary
Multipotent stromal cells (MSC) and their osteoblastic lineage cell (OBC) derivatives are part of the bone marrow (BM) niche and contribute to hematopoietic stem cell (HSC) maintenance. During myeloproliferative neoplasm (MPN) development, MSCs are stimulated to overproduce functtionally altered OBCs, which accumulate in the BM cavity as myelofibrotic cells. These MPN-expanded OBCs, in turn, impair the maintenance of normal HSCs but not of leukemic stem cells. We used microarrays to detail the global gene expression changes in OBCs during BCR/ABL-induced MPN development, and understand the molecular deregulations contributing to their functional changes.
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Also filed as BioProject PRJNA210141. Searching any of these in the dataset finder brings you back here.

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