Plasticity and lineage commitment of individual Th1 cells are determined by stable T-bet expression quantities
RNA-seq (gene expression) · mouse · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 7 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Plasticity and lineage commitment of individual T(H)1 cells are determined by stable T-bet expression quantitiesScience advances · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE266174_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1106058 and SRA study SRP504781. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 7 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8241844 Naive_SM_Th2_R1 Naive_SM_Th2
- GSM8241845 Naive_SM_Th2_R2 Naive_SM_Th2
- GSM8241846 WT_Neutral_R1 WT_Neutral
- GSM8241847 WT_Neutral_R2 WT_Neutral
- GSM8241848 Het_Neutral_R1 Het_Neutral
- GSM8241849 Het_Neutral_R2 Het_Neutral
- GSM8241850 KO_Neutral_R1 KO_Neutral
- GSM8241851 KO_Neutral_R2 KO_Neutral
- GSM8241852 WT_Th2_R1 WT_Th2
- GSM8241853 WT_Th2_R2 WT_Th2
- GSM8241854 Het_Th2_R1 Het_Th2
- GSM8241855 Het_Th2_R2 Het_Th2
- GSM8241856 KO_Th2_R1 KO_Th2
- GSM8241857 KO_Th2_R2 KO_Th2
- GSE266175 Plasticity and lineage commitment of individual Th1 cells are determined by stable T-bet expression quantities (ChIP-Seq) 84 samples shares plasticity, commitment, individual, determined, quantities, lineage, stable, t-bet
- GSE308931 Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge 10 samples shares commitment, lineage, stable
- GSE288156 Progressive intestinal tumor cell plasticity, Myc activation and loss of Lgr5+ tumor stem cell lineage commitment upon Wnt depletion 14 samples shares plasticity, commitment, lineage
- GSE298006 Stage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [RNA-Seq] 110 samples shares commitment, lineage
- GSE309033 Combined BET Bromodomain and DNMT Inhibition Targets Lineage Plasticity in Prostate Cancer [BETi_DNMTi_mouse_RNAseq] 51 samples shares plasticity, lineage
- GSE39656 Braveheart is a long non-coding RNA necessary for cardiac lineage commitment 20 samples shares commitment, lineage
- GSE293719 Beclin1 Deficiency Unlocks Cardiac Lineage Commitment through Convergent Wnt and BMP Signaling Activation 16 samples shares commitment, lineage
- GSE290752 Lineage Plasticity Driven by GATA6 Loss Fuels Colorectal Cancer Metastasis [RNA-seq_met] 15 samples shares plasticity, lineage
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.