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Transcriptional analysis of human blood CXCR5+ CD4 T cell populations

GSE50390 Homo sapiens Expression profiling by array 24 samples Submitted 2013/11/12 Platform GPL10558
Summary
The vast majority of currently licensed human vaccines work on the basis of long-term protective antibody responses. Generation of long term humoral immunity is a complex process predominantly dependent on germinal centers and CD4 T cell help to B cells. Follicular helper T cells (Tfh) are the specialized CD4 T cells for B cell help. However, whether such cells develop memory in humans and can be tracked in human blood has been enigmatic. We identified a subpopulation of blood CXCR5+ PD-1+CXCR3- resting CD4 T cells that are most related to Tfh cells of lymphoid tissue by gene expression profile and phenotype. Functional analysis showed that these memory Tfh cells were specialized for helping B cells. Moreover, these cells correlate with a clinically important outcome: development of potent neutralizing antibodies against HIV in HIV+ individuals.
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Direct links to NCBI, no account and no request form: the whole study as GSE50390_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 24 samples.

Also filed as BioProject PRJNA217400. Searching any of these in the dataset finder brings you back here.

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