Targeting transcriptional dependencies in cancer using a covalent CDK7 inhibitor
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 92 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 92 samples
- Data you can get
- A processed expression table (series matrix) and the array files, from NCBI.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE50625_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA218102 and SRA study SRP029600. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 92 more — browse all 92 samples with per-sample file links →
- GSE240492 Targeting axonal guidance dependencies in glioblastoma with ROBO1 CAR T cells 41 samples shares dependencies, targeting
- GSE218269 CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release 100 samples shares cdk7
- GSE228346 The TFIIH kinase CDK7 governs RNA polymerase II initiation, elongation, termination, and RNA processing 30 samples shares cdk7
- GSE300378 Targeting Thioredoxin Reductase 1 (TrxR1) Uncovers Ferroptosis-Linked Transcriptional Vulnerabilities in Lung Cancer 33 samples shares targeting
- GSE222196 Treatment of prostate cancer cell lines with Androgen Receptor and Receptor Tyrosine Kinase inhibitors 246 samples shares inhibitor
- GSE281556 Lysosomal sequestration of PARP inhibitors drives heterogeneous accumulation in ovarian cancer to increase efficacy 204 samples shares inhibitor
- GSE328578 CBFA2T3-GLIS2 fusion-mediated mSWI/SNF chromatin remodeler disruption generates cancer-specific dependencies in AMKL 156 samples shares dependencies
- GSE222557 Neoadjuvant PARPi or Chemotherapy in Ovarian Cancer Informs Targeting Effector Treg Cells for Homologous-Recombination-Deficient Tumors 148 samples shares targeting
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.