GEO series

Identifying an Apical Ectodermal Ridge (AER) signature in embryonic day 11.5 mouse forelimb.

GSE51877 Mus musculus (mouse) Expression microarray 7 samples Submitted 2013/11/15 Platform GPL13912

At a glance

Expression microarray · mouse · 7 samples

What it is: Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
Organism: Mus musculus (mouse)
Samples: 7 samples
Data you can get: A processed expression table (series matrix) and the array files, from NCBI.

Summary (written by the submitters)

The apical ectodermal ridge (AER) is a transient ectodermal population of cells that defines the dorso-ventral border of the developing limb bud. It functions as a major signaling centre that, through the secretion of various growth factors including FGF8, instructs the growth and patterning of the developing limb. We have identified that the AER expresses markers of cellular senescence and wanted to examine if there was any overlap with oncogene-induced senescence, an adult form of senescence induced in premalignant lesions.

Read the full summary ↓

To achieve this, we microdissected the AER from embryonic day 11.5 mouse embryos. In addition, we collected the surface ectoderm from the proximal limb bud, that was not senescent and profiled both populations, to identify those genes that are enriched in the AER

This dataset

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Download · which file do I need?

Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need.

All supplementary files ↗

3 · The original raw files

Whole study · RAW.tar

Everything the authors deposited as one archive (GSE51877_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.

Whole study · RAW.tar ↓

What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.

Also filed as BioProject PRJNA225645. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 24238961) ↗

Samples in this study

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+ 7 more — browse all 7 samples with per-sample file links →

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