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Obesity-associated variants within FTO form long-range functional connections with IRX3

GSE52830 Danio rerio; Mus musculus Other 6 samples Submitted 2014/02/24 Platform GPL13112Platform GPL14875
Summary
Genome-wide association studies in diverse populations have reproducibly associated variants within introns of FTO with increased risk for obesity and type-2 diabetes.While the molecular mechanisms linking these noncoding variants with obesity are not immediately obvious, subsequent studies in mice demonstrated that FTO expression levels influence body mass and composition phenotypes. Yet, no direct connection between the obesity-associated intronic variants and FTO expression or function has been made. We show that the obesity-associated noncoding sequences within FTO are functionally connected, at megabase distances, primarily with the homeobox gene IRX3, rather than with FTO.
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Also filed as BioProject PRJNA230260 and SRA study SRP033390. Searching any of these in the dataset finder brings you back here.

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