GEO series

Gene expression analysis of T-ALL cell lines treated with gamma-secretase inhibitor

GSE5716 Homo sapiens Expression profiling by array 40 samples Submitted 2008/08/20 Platform GPL570

Summary

Gain-of-function mutations in NOTCH1 are common in T-cell lymphoblastic leukemias making this receptor a promising target for drugs such as gamma-secretase inhibitors (GSI), which block a proteolytic cleavage required for NOTCH1 activation. However, the enthusiasm for these therapies has been tempered by tumor resistance and the paucity of information on the oncogenic programs regulated by oncogenic NOTCH1. Analysis of gene expression in GSI-responsive and GSI-resistant cell lines treated with Compound E identifies differential resopnses to GSI. Keywords: Drug response

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Direct links to NCBI, no account and no request form: the whole study as GSE5716_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 40 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA97007. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 17873882) ↗

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