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Dynamic profiling of the protein life cycle in response to pathogens (RNA-seq)

GSE59784 Mus musculus Expression profiling by high throughput sequencing 28 samples Submitted 2015/03/06 Platform GPL17021
Summary
Protein expression is regulated by production and degradation of mRNAs and proteins, but their specific relationships remain unknown. We combine measurements of protein production and degradation and mRNA dynamics to build a quantitative genomic model of the differential regulation of gene expression in LPS stimulated mouse dendritic cells. Changes in mRNA abundance play a dominant role in determining most dynamic fold changes in protein levels. Conversely, the preexisting proteome of proteins performing basic cellular functions is remodeled primarily through changes in protein production or degradation, accounting for over half of the absolute change in protein molecules in the cell. Thus, the proteome is regulated by transcriptional induction of novel cellular functions and remodeling of preexisting functions through the protein life cycle.
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Also filed as BioProject PRJNA256196 and SRA study SRP044873. Searching any of these in the dataset finder brings you back here.

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