GEO series

Continuous requirement for the T cell receptor for regulatory T cell function

GSE61077 Mus musculus Expression profiling by array 10 samples Submitted 2014/09/08 Platform GPL8321

Summary

Foxp3+ regulatory T cells (Treg cells) maintain immunological tolerance and their deficiency results in fatal multi-organ autoimmunity. Although heightened T cell receptor (TCR) signaling is critical for the differentiation of Treg cells, the role of TCR signaling in Treg cell function remains largely unknown. Here we demonstrate inducible ablation of the TCR results in Treg cell dysfunction which cannot be attributed to impaired Foxp3 expression, decreased expression of Treg cell signature genes or altered ability to sense and consume interleukin 2. Rather, TCR signaling was required for maintaining the expression of a limited subset of genes comprising 25% of the activated Treg cell transcriptional signature. Our results reveal a critical role for the TCR in Treg cell suppressor capacity.

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Direct links to NCBI, no account and no request form: the whole study as GSE61077_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 10 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA260295. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 25263123) ↗

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