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Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed

GSE65926 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing 25 samples Submitted 2015/04/24 Platform GPL11154Platform GPL13112Platform GPL16791Platform GPL17021
Summary
Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their abundance, their function and expression in the nervous system are unknown. Therefore, we sequenced RNA from different brain regions, primary neurons, isolated synapses, as well as during neuronal differentiation. Using these and other available data, we discovered and analyzed thousands of neuronal human and mouse circRNAs. circRNAs were extraordinarily enriched in the mammalian brain, well conserved in sequence, often expressed as circRNAs in both human and mouse, and sometimes even detected in Drosophila brains. circRNAs were overall upregulated during neuronal differentiation, highly enriched in synapses, and often differentially expressed compared to their mRNA isoforms. circRNA expression correlated negatively with expression of the RNA-editing enzyme ADAR1. Knockdown of ADAR1 induced elevated circRNA expression. Together, we provide a circRNA brain expression atlas and evidence for important circRNA functions and values as biomarkers.
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Also filed as BioProject PRJNA275421 and SRA study SRP055027. Searching any of these in the dataset finder brings you back here.

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