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Response of IRF7-deficient peripheral blood mononuclear cells to pH1N1 influenza virus infection

GSE66486 Homo sapiens Expression profiling by array 18 samples Submitted 2015/04/07 Platform GPL10558
Summary
IRF7 plays a critical role in the production and amplification of the antiviral type I and III interferon response. Autosomal recessive IRF7-deficiency resulted in life-threatening influenza disease in a 3-year-old child. We studied the impact of IRF7-deficiency in non-hematopoietic tissues (fibroblasts and lung epithelial cells) as well in hematopoietic cells (peripheral blood mononuclear cells (PBMCs)). Genome-wide gene expression analysis demonstrated a profound loss of type I and III IFNs in PBMCs infected with influenza virus.
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Also filed as BioProject PRJNA277057. Searching any of these in the dataset finder brings you back here.

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