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Parallel single-cell bisulfite- and RNA-sequencing link transcriptional and epigenetic heterogeneity [Bisulfite-Seq]

GSE68642 Mus musculus Methylation profiling by high throughput sequencing 96 samples Submitted 2015/12/24 Platform GPL13112
Summary
We report scM&T-seq, a method for parallel single-cell genome-wide methylome and transcriptome sequencing, allowing discovery of associations between transcriptional and epigenetic variation. Profiling of 61 mouse embryonic stem cells confirmed known links between DNA methylation and transcription. Notably, the method reveals novel associations between heterogeneous methylation of distal regulatory elements and transcriptional heterogeneity of key pluripotency genes.
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Direct links to NCBI, no account and no request form: the whole study as GSE68642_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 96 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA283282 and SRA study SRP058091. Searching any of these in the dataset finder brings you back here.

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