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Pathogenicity of genomic duplications is determined by formation of novel chromatin domains (neo-TADs) (RNA-seq)

GSE78105 Mus musculus Expression profiling by high throughput sequencing 17 samples Submitted 2016/10/06 Platform GPL17021
Summary
Genome-scale methods have identified subchromosomal structures so-called topologically associated domains (TADs) that subdivide the genome into discrete regulatory units, establish with their target genes. By re-engineering human duplications at the SOX9 locus in mice combined with 4C-seq and Capture Hi-C experiments, we show that genomic duplications can result in the formation of novel chromatin domains (neo-TADs) and that this process determines their molecular pathology.
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Also filed as BioProject PRJNA312623 and SRA study SRP070571. Searching any of these in the dataset finder brings you back here.

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