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Epigenome maps of time-resolved monocyte to macrophage differentiation and innate immune memory (ATAC-Seq)

GSE87218 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 13 samples Submitted 2016/11/18 Platform GPL18573
Summary
Innate immune memory is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to microbial components such as LPS. We apply an integrated epigenomic approach to characterize the molecular events involved in LPS-induced tolerance in a time dependent manner. ChIP-seq, RNA-seq, WGBS and ATAC-seq data were generated. This analysis identified epigenetic programs in tolerance and trained macrophages, and the potential transcription factors involved.
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Direct links to NCBI, no account and no request form: the whole study as GSE87218_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 13 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA343921 and SRA study SRP090300. Searching any of these in the dataset finder brings you back here.

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