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Transcriptional response to early life stress in male and female mouse brain

GSE89692 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 179 samples Submitted 2017/06/28 Platform GPL13112Platform GPL17021
Summary
This study explored the interaction of early life and adult stress on transcriptional and chromosomal states in a 2x2 design. Male and female mice were subjected to early life stress (ELS) or were standard-reared (Std), were housed normally through adolescence, and were then exposed to 10 days of control (Ctl) or chronic social defeat stress (CSDS: males only) or 3 days of sub-threshold variable stress (STVS: females only) conditions in adulthood. Long-lasting transcriptional alterations were assessed in the ventral tegmental area (VTA), nucleus accumbens (NAc), medial prefrontal cortex (PFC), and ventral hippocampus (HIP, males only) in adulthood.
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Direct links to NCBI, no account and no request form: the whole study as GSE89692_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 179 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA352967 and SRA study SRP093288. Searching any of these in the dataset finder brings you back here.

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