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Steatohepatitis progresses to cancer via immunosuppression of HCC directed CD8+ T cells

GSE90497 Mus musculus Expression profiling by high throughput sequencing 41 samples Submitted 2017/09/08 Platform GPL17021
Summary
We show that chronic inflammation and fibrosis in mice with non-alcoholic fatty liver disease (NASH) is accompanied by accumulation of immunoglobulin A (IgA) positive plasmocytes. These cells suppress activation of cytotoxic T cells (CTL) derived from liver infiltrating CD8+ cells. CD8+ T cell ablation greatly accelerates HCC appearance, genetic or pharmacological targeting of IgA and PD-L1 expressing plasmocytes attenuates hepatic carcinogenesis and induces CTL-dependent regression of established HCC.
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Also filed as BioProject PRJNA354910 and SRA study SRP093912. Searching any of these in the dataset finder brings you back here.

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