Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch
RNA-seq (gene expression) · mouse · 8 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 8 samples: 4 × Control vs 4 × MC903Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE90883_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA356278 and SRA study SRP094566. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 2 replicated groups read from 8 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM2416953 Control Rep1 Control
- GSM2416954 Control Rep2 Control
- GSM2416955 Control Rep3 Control
- GSM2416956 Control Rep4 Control
- GSM2416957 MC903 Rep1 MC903
- GSM2416958 MC903 Rep2 MC903
- GSM2416959 MC903 Rep3 MC903
- GSM2416960 MC903 Rep4 MC903
- GSE191016 Planar cell polarity proteins mediate ketamine-induced restoration of glutamatergic synapses in prefrontal cortical neurons in a mouse model for chronic stress 20 samples shares neurons, mediate, chronic
- GSE329323 Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded ATXN3 [Advil RNA-seq] 18 samples shares sensory, neurons
- GSE301327 RiboTag and bulk RNA sequencing using AAV-Control and AAV-shLarp1 infected sensory neurons. 12 samples shares sensory, neurons
- GSE301320 RiboTag and bulk RNA sequencing using AAV-Control and AAV-shCsde1 infected sensory neurons. 12 samples shares sensory, neurons
- GSE199288 Perivascular fibrosis is mediated by a KLF10-IL-9 signaling axis in CD4+ T cells 27 samples shares mediate
- GSE303716 Nodal/Smad2 signaling sustains developmental pausing by repressing Pparg -mediated lipid metabolism [RNA-Seq] 24 samples shares mediate
- GSE261642 PLPP1-deficiency-mediated ferroptosis induced by PD-1 signaling impairs antitumor activity of intratumoral CD8+ T cells I 23 samples shares mediate
- GSE241176 Fibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes [RNA-seq: Smad3 in dbdb] 12 samples shares mediate
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.