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High-throughput RNA-sequencing of preadipocyte subsets in obese mice

GSE93697 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/12/31 Platform GPL13112
Summary
We identified a population of obesity-promoted adipogenic preadipocytes that co-expressed Fabp4 and ICAM-1. Fabp4-Cre;mTmG mice were treated with high-fat diet for 16 weeks. The inguinal adipose tissues were collected and digested to obtain vascular and stromal fractions (SVF). The mature adipocytes, CD31-CD45-Sca-1+PDGFR-α+ICAM-1+EGFP+, CD31-CD45-Sca-1+PDGFR-α+ICAM-1+EGFP-, CD31-CD45-Sca-1+PDGFR-α+ICAM-1- cell population were isolated for RNA-seq.
Published in
ICAM-1 identifies preadipocytes and restricts white adipogenesis by adhering immune cells
Zheng C, Ye J, Yang Q et al. · Cell death and differentiation 2026 · PMID 40813463 · doi:10.1038/s41418-025-01551-2
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Also filed as BioProject PRJNA361574 and SRA study SRP096875. Searching any of these in the dataset finder brings you back here.

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