GEO series

Genes up-regulated by VE-cadherin expression and clustering at junctions

GSE11674 Mus musculus Expression profiling by array 16 samples Submitted 2008/07/06 Platform GPL81Platform GPL82

Summary

In order to identify genes regulated by VE-cadherin expression, we compared a mouse VE-cadherin null cell line (VEC null) with the same line reconstituted with VE-cadherin wild type cDNA (VEC positive). The morphological and functional properties of these cell lines were described previously [Lampugnani,M.G. et al. Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J. Cell Biol. 161, 793-804 (2003)]. By Affymetrix gene expression analysis we found several genes up-regulated by VE-cadherin, among which claudin-5 reached remarkably high levels. The up-regulation of these genes required not only VE-cadherin expression but also cell confluence suggesting that VE-cadherin clustering at junctions was needed.

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Direct links to NCBI, no account and no request form: the whole study as GSE11674_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 16 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA106073. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 18604199) ↗

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