Transcriptional coactivator MED15 is required for beta cell maturation
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 31 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 31 samples: 11 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Transcriptional coactivator MED15 is required for beta cell maturationNature communications · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE137145_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA564631 and SRA study SRP221151. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 5 samples read as cases, 11 as controls.
How we read this: 11 replicated groups read from 31 sample titles; they account for 31 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM4071982 Input_MIN6_rep1 Input_MIN6
- GSM4071983 Med15_MIN6_rep1 Med15_MIN6
- GSM4071984 Med1_MIN6_rep1 Med1_MIN6
- GSM4071985 Input_MIN6_rep2 Input_MIN6
- GSM4071986 Med15_MIN6_rep2 Med15_MIN6
- GSM4071987 Med1_MIN6_rep2 Med1_MIN6
- GSM4071988 Input_MIN6_rep3 Input_MIN6
- GSM4071989 Med15_MIN6_rep3 Med15_MIN6
- GSM4071990 Med1_MIN6_rep3 Med1_MIN6
- GSM4071991 Input_CTRL_rep1 Input_CTRL
- GSM4071992 Med15_CTRL_rep1 Med15_CTRL
- GSM4071993 Med1_CTRL_rep1 Med1_CTRL
- GSM4071994 Input_IM15KO_rep1 Input_IM15KO
- GSM4071995 Med15_IM15KO_rep1 Med15_IM15KO
- GSM4071996 Med1_IM15KO_rep1 Med1_IM15KO
- GSM4071997 Input_CTRL_rep2 Input_CTRL
- GSM4071998 Med15_CTRL_rep2 Med15_CTRL
- GSM4071999 Med1_CTRL_rep2 Med1_CTRL
- GSM4072000 Input_IM15KO_rep2 Input_IM15KO
- GSM4072001 Med15_IM15KO_rep2 Med15_IM15KO
- GSM4072002 Med1_IM15KO_rep2 Med1_IM15KO
- GSM8499617 islets, wildtype, rep1 islets, wildtype,
- GSM8499618 islets, knockout, rep1 islets, knockout,
- GSM8499619 islets, wildtype, rep2 islets, wildtype,
- GSM8499620 islets, knockout, rep2 islets, knockout,
- GSM8499621 islets, knockout, rep3 islets, knockout,
- GSM8499622 islets, wildtype, rep3 islets, wildtype,
- GSM8499623 islets, knockout, rep4 islets, knockout,
- GSM8499624 islets, wildtype, rep4 islets, wildtype,
- GSM8499625 islets, knockout, rep5 islets, knockout,
- GSM8499626 islets, wildtype, rep5 islets, wildtype,
- GSE241408 Declining FXR expression coordinates neonatal beta cell mass development with microbial bile acid metabolism maturation in mice 12 samples shares maturation, beta
- GSE281035 PAR3-mediated coordination of hepatocyte proliferation, maturation, and architecture in liver development and regeneration 128 samples shares maturation
- GSE288059 CFP1 promotes germinal center affinity maturation and restrains and memory B cell differentiation through H3K4me3 modulation 12 samples shares maturation
- GSE240860 Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner 54 samples shares maturation
- GSE249055 Casz1 is required for both inner hair cell fate stabilization and outer hair cell survival 73 samples shares required
- GSE283275 THAP1 is a maternal effect factor required for the first cell cycle via Rrm1 in early mouse embryos 44 samples shares required
- GSE248181 Maternal SMARCA5 is required for major ZGA in mouse 251 samples shares required
- GSE325932 Disease-associated microRNA, miR-9-2, is required for the timing of retinal progenitor cell competence and the maintenance of Müller glial identity 32 samples shares required
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.