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Light augments antidepressant response via astroglial modulation of lateral habenula

GSE143820 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/12 Platform GPL17021
Summary
Successful antidepressant treatments are still difficult to achieve. Recently, bright light stimulation (BLS) was shown effective in non-seasonal depression but its mode of action remains elusive. We demonstrate, using a new mouse model of depression resistant to antidepressants including ketamine, that both chemogenetic activation of lateral habenula (LHb) astroglia and serotonin (5-HT) depletion prevented the potentiating effect of BLS on the antidepressant response. These results show that improved behavioral outcome produced by BLS requires habenular astroglia and 5-HT tone as crucial buffer systems.
Published in
Lateral habenula astroglia modulate the potentiating antidepressant-like effects of bright light stimulation in intractable depression
Delcourte S, Bouloufa A, Rovera R et al. · Frontiers in pharmacology 2025 · PMID 40337515 · doi:10.3389/fphar.2025.1592909
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Also filed as BioProject PRJNA601773 and SRA study SRP242306. Searching any of these in the dataset finder brings you back here.

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