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Impaired social cognition caused by perinatal protein malnutrition evokes psychiatric-like disorders and is intergenerationally transmitted.

GSE156887 Mus musculus (mouse) RNA-seq (gene expression) 10 samples Submitted 2025/08/25 Platform GPL18480
At a glance

RNA-seq (gene expression) · mouse · 10 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
10 samples
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Summary (written by the submitters)
Maternal malnutrition remains one the major early-life adversities contributing poor health in one in five children worldwide. Clinical studies demonstrate that malnourished children are growth-impaired, exhibit behavioral changes and suffer from cognitive impairments. These health effects can persist even if nutrition becomes adequate later in life.
Read the full summary ↓
Experimental studies on rodents have shown that maternal protein restriction is associated with the emergence of several adverse effects of offspring neurological development. In addition, reported effects of prenatal and/or postnatal protein malnutrition on the offspring include changes in exploratory behavior and anxiety, altered learning and memory abilities and a different response to aversive stimuli. These behavioral alterations characterize the symptoms of various psychiatric disorders that has been increasingly regarded as developmental disorders. Social behavioral deficits in psychiatric diseases have been hypothesized to arise form elevation in the cellular balance of excitation and inhibition within the cortex generally, and PFC specifically. Such imbalance may be caused either by increased activity in excitatory neurons or by reduction in inhibitory neuron function. Interestingly, decreases in inhibitory neurotransmission are a common finding in animal models of ASD. In addition, direct alterations of E/I balance within the PFC in adult mice have strong effect on social motivation. The critical question we have posed in this work is whether maternal protein malnutrition alters the offspring’s social cognition and if this were the case, if these behavioral deficits are transmitted to the following generation. We hypothesized that at the basis of such alterations in social cognition underlie changes in gene expression related to E/I signaling within the mPFC. Our results focus on damaging effects of maternal protein malnutrition even for generations that are not exposed to this environmental adversity.
This dataset
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Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE156887_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA659480 and SRA study SRP279006. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗
Samples in this study

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