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Cpt2 knockout in muscle stem cells

GSE158912 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/07/31 Platform GPL13112
Summary
Analysis of skeletal muscle satellite cells with specific knockout (KO) of Carnitine Palmitoyltransferase 2 (Cpt2) gene in mouse (named Cpt2PKO). Cpt2 knockout disrupts fatty acid oxidation in satellite cells and causes energy insufficiency and alteration of protein acetylation, which eventually impedes their expansion and differentiation, leading to impairments in muscle regeneration.
Published in
Mitochondrial fatty acid oxidation regulates adult muscle stem cell function through modulating metabolic flux and protein acetylation
Yue F, Gu L, Qiu J et al. · The EMBO journal 2025 · PMID 40065099 · doi:10.1038/s44318-025-00397-1
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Also filed as BioProject PRJNA666937 and SRA study SRP286137. Searching any of these in the dataset finder brings you back here.

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