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Loss of retinoic acid signaling drives immune escape in IDH mutant gliomas

GSE172387 Mus musculus Expression profiling by high throughput sequencing; Other 4 samples Submitted 2024/04/19 Platform GPL24247
Summary
Gliomas are immunologically cold tumors that can be broken into several categories based on either RNA expression profiles or methylation profiles, with isocitrate dehydrogenase (IDH) mutations defining a major segregration between types. IDH mutant gliomas often exhibit defects in the retinoic acid pathway. We treated mice harboring IDH mutant gliomas with all-trans retinoic acid, and found that this treatment cause reductions in tumor growth and a swith in immune profiles in the tumor microenvironment.
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Also filed as BioProject PRJNA723194 and SRA study SRP315506. Searching any of these in the dataset finder brings you back here.

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