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Regulation of adipogenesis via caveolin-1 in adipose derived mesenchymal stem cells

GSE183289 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/12/15 Platform GPL18573
Summary
Using human adipose derived mesenchymal stem cells (ASCs) as a model system, we identified caveolae forming structural protein, caveolin-1 (CAV1) as a key component that limits adipogenic differentiation of ASCs. Using whole transcriptomic analysis by RNA sequencing, we show that lentiviral over expression of human CAV1 gene in ASCs significantly inhibits adipogenesis as evident by inhibition of adipogenic gene network, and conversely, RNAi driven knockdown of endogenous CAV1 significantly promoted adipogenesis.
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Also filed as BioProject PRJNA759888 and SRA study SRP335414. Searching any of these in the dataset finder brings you back here.

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