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Comparison of mRNA expression level between AmTARS and Pam3 as a lignad of TLR2 receptor

GSE183968 Mus musculus (mouse) RNA-seq (gene expression) 10 samples Submitted 2024/09/02 Platform GPL13112
At a glance

RNA-seq (gene expression) · mouse · 10 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
10 samples
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasisCell host & microbe · 2023
Summary (written by the submitters)
We demonstrated that AmTARS directly binds TLR2 receptor. Thus, we analysis mRNA expression pattern in mouse bone-marrow-derived macrophage (BMDM) treated with AmTARS and Pam3csk4 known as the TLR2 agonist.
Published in
Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis
Kim SM, Park S, Hwang SH et al. · Cell host & microbe 2023 · PMID 37269833 · doi:10.1016/j.chom.2023.05.007
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE183968_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA762551 and SRA study SRP336728. Searching any of these in the dataset finder brings you back here.

Samples in this study

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