Genome-wide changes in RNAPII occupancy and phosphorylation in response to CDK12/13 inhibition in gliomas
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 14 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples: 14 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastomaEMBO molecular medicine · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE186309_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA773376 and SRA study SRP342519. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 14 sample titles: 14 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM5643594 G7_Input_1hr_THZ531
- GSM5643595 G7_Input_6hrs_THZ531
- GSM5643596 G7_Input_6hrs_DMSO
- GSM5643597 G7_H3K27ac_6hrs_DMSO
- GSM5643598 G7_H3K27me3_6hrs_DMSO
- GSM5643599 G7_RNAPolII_1hr_THZ531
- GSM5643600 G7_RNAPolII_6hrs_THZ531
- GSM5643601 G7_RNAPolII_6hrs_DMSO
- GSM5643602 G7_RNAPolIIS2P_1hr_THZ531
- GSM5643603 G7_RNAPolIIS2P_6hrs_THZ531
- GSM5643604 G7_RNAPolIIS2P_6hrs_DMSO
- GSM5643605 G7_RNAPolIIS5P_1hr_THZ531
- GSM5643606 G7_RNAPolIIS5P_6hrs_THZ531
- GSM5643607 G7_RNAPolIIS5P_6hrs_DMSO
- GSE186311 Genome-wide changes in RNAPII occupancy, RNAPII phosphorylation, and transcription in response to CDK12/13 inhibition in gliomas 20 samples shares rnapii, cdk12, phosphorylation, genome-wide, inhibition, occupancy, changes, gliomas
- GSE311170 Combining CDK12 and BAF inhibition synergistically impairs cancer cell survival in triple-negative breast cancer line 66 samples shares cdk12, inhibition
- GSE307861 Maintenance of gene expression homeostasis by systems-level feedback loops in response to changes in RNA polymerase II dosage [RNAPII_levels_mRNAseq] 42 samples shares rnapii, changes
- GSE288707 CDK12/13 inhibition in NSCLC cell lines with acquired resistance to sotorasib 24 samples shares cdk12, inhibition
- GSE249941 ZNF292 genome-wide occupancy during cortical interneuron development 31 samples shares genome-wide, occupancy
- GSE324916 Phosphorylation of serines 287/288 in DEK regulates cell-type-specific chromatin occupancy and compaction [ChIP-Seq] 24 samples shares phosphorylation, occupancy
- GSE303100 Dissecting Resistance to CDK4/6 Inhibition in Experimental Glioma via Genome-wide CRISPR-Cas9 Screening 24 samples shares genome-wide, inhibition
- GSE316989 Targeting CDK12/CYCLIN K induces a gene activation program which is mediated by P-TEFb [Cut&RUN] 10 samples shares cdk12
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.