Transforming Growth Factor-β (TGFβ) Prevents Hypertension-Induced Aortic Dissection in Adult Mice via Extracellular Matrix Production (Bulk KO vs. WT SMC)
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE194082_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA799021 and SRA study SRP355990. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM5827436 WT1-ASC (Bulk KO vs. WT SMC)
- GSM5827437 WT1-DESC (Bulk KO vs. WT SMC)
- GSM5827438 WT2-ASC (Bulk KO vs. WT SMC)
- GSM5827439 WT2-DESC (Bulk KO vs. WT SMC)
- GSM5827440 WT3-ASC (Bulk KO vs. WT SMC)
- GSM5827441 WT3-DESC (Bulk KO vs. WT SMC)
- GSM5827442 KO1-ASC (Bulk KO vs. WT SMC)
- GSM5827443 KO1-DESC (Bulk KO vs. WT SMC)
- GSM5827444 KO2-ASC (Bulk KO vs. WT SMC)
- GSM5827445 KO2-DESC (Bulk KO vs. WT SMC)
- GSM5827446 KO3-ASC (Bulk KO vs. WT SMC)
- GSM5827447 KO3-DESC (Bulk KO vs. WT SMC)
- GSE294868 Loss of EGFR prevents the synergistic early-phase impact of obesity-associated metabolic and humoral stress on primary VSMC – stressor synergy, sex-dependence 69 samples shares smc, prevents
- GSE271355 Galectin 3-binding protein (Lgals3bp) depletion attenuates hepatic fibrosis by reducing transforming growth factor-β1 (TGF-β1) availability and inhibits hepatocarcinogenesis [PH RNA-seq] 12 samples shares tgf, transforming
- GSE301501 Extracellular matrix reprogramming by the YAP/TAZ/TGF-ß2 axis drives immune exclusion in cholangiocarcinoma models 45 samples shares tgf, extracellular
- GSE254410 In the aftermath of stroke or myocardial infarction, neutrophil extracellular traps disrupt systemic immunoglobulin production 12 samples shares extracellular, production
- GSE284085 The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage. 12 samples shares extracellular, production
- GSE75111 Single-cell transcriptional profiling of Th17 cells, differentiated in vitro for 48h [TGFB1_IL6-48h-IL-17A/GFP+] 151 samples shares tgf
- GSE268757 Reproducible lung protective effects of a TGFβR1/ALK5 inhibitor in the bleomycin-induced and spirometry-confirmed mouse model of IPF 75 samples shares tgf
- GSE270744 Single Cell Analysis Reveals The Essential Role of TGFbeta Pathway in Shaping Immune-suppressive Microenvironment and Promoting CRPC Development 48 samples shares tgf
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.