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Expression data from splenic T cells at day7 during MOG-induced mouse EAE model

GSE197869 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/03/02 Platform GPL30215
Summary
Regulatory T cells (Tregs) are indispensable for maintaining immunological homeostasis and preventing autoimmune diseases. IRE1a is an ER-resident transmembrane protein kinase/endoribonuclease that initiates a critical signaling branch of the unfolded protein response (UPR). We aim to search for genes change of Tregs and Teffs from WT (Foxp3Cre)and IRE1a-/-(KO) mice in the context of MOG-induced experimental autoimmune encephalomyelitis. Our results reveal an important mechanism that links the IRE1a branch of the UPR to experimental autoimmune encephalomyelitis(EAE) model, showing IRE1a affects Tregs suppressive function via mediating HDAC9 upregulation. Our findings suggest that Treg IRE1a is a valuable therapeutic target against multiple sclerosis and other autoimmue diseases.
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Direct links to NCBI, no account and no request form: the whole study as GSE197869_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA812538 and SRA study SRP362335. Searching any of these in the dataset finder brings you back here.

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