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Single cell multiomic landscape reveals gene programs driving lipid droplet heterogeneity in hepatic steatosis

GSE199064 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2026/04/01 Platform GPL21103
Summary
Alcohol-associated liver disease (ALD) in its earliest form is evidenced as hepatic steatosis which may progress to liver cirrhosis. Using single-cell multiomics technology, we studied transcriptional mechanisms across the hepatic lobule that could account for liver zonation of lipid droplets in a murine ALD model. Furthermore, chromatin landscape studies demonstrated zonation of regulatory elements and master transcription factors associated with these changes in the transcriptome.
Published in
Single cell multiomic landscape reveals gene programs driving lipid droplet heterogeneity in hepatic steatosis
Sehrawat TS, Cooper SA, Navarro-Corcuera A et al. · Scientific reports 2026 · PMID 41730984 · doi:10.1038/s41598-026-39913-6
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Also filed as BioProject PRJNA818264 and SRA study SRP365058. Searching any of these in the dataset finder brings you back here.

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