Inhibition of lysine demethylase 6B blocks the development of ASXL1 truncation-mediated myeloid malignancies [RNA-seq]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE208054_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA858065 and SRA study SRP386069. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 12 more — browse all 12 samples with per-sample file links →
- GSE208249 Inhibition of lysine demethylase 6B blocks the development of ASXL1 truncation-mediated myeloid malignancies 28 samples shares asxl1, truncation-mediated, malignancies, demethylase, inhibition, myeloid, lysine
- GSE208246 Inhibition of lysine demethylase 6B blocks the development of ASXL1 truncation-mediated myeloid malignancies [ChIP-seq] 16 samples shares asxl1, truncation-mediated, malignancies, demethylase, inhibition, myeloid, lysine
- GSE286398 Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation [scRNA-seq] 13 samples shares demethylase, myeloid, rna-seq, lysine
- GSE214680 The histone H3 lysine 36 demethylase KDM2A/FBXL11 is essential for germ cell development in male mice [RNA-Seq] 24 samples shares demethylase, rna-seq, lysine
- GSE291446 T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis [RNA-seq] 20 samples shares demethylase, rna-seq, lysine
- GSE266091 Asxl1 mutation enhances differentiation in CSF3R-mutated myeloproliferative neoplasms [RNA-Seq] 12 samples shares asxl1, rna-seq
- GSE276811 Fructose feeding on Asxl1-mutant clonal hematopoiesis [single-cell RNA-seq] 12 samples shares asxl1, rna-seq
- GSE279601 Clonal Haematopoiesis-related Mutant ASXL1 Promotes Atherosclerosis in Mice via Dysregulated Innate Immunity [scRNA-seq] 4 samples shares asxl1, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.