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Glucocorticoid Receptor Signaling is Critical for Mouse Corneal Development, Inhibition of Inflammatory Response and Neovascularization of the Cornea

GSE213571 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/06/27 Platform GPL19057
Summary
Synthetic glucocorticoids are widely prescribed in the treatment of ocular infections and disorders. The actions of glucocorticoids are mediated by the glucocorticoid receptor (GR); however, the molecular and physiological functions of GR signaling in the cornea are poorly understood. In this study, we show that treatment of mice with glucocorticoid eye drops led to a profound regulation of the corneal transcriptome. To determine the global transcriptional profile of GR activity in the cornea, we treated adult wild-type male mice with dexamethasone (a synthetic glucocorticoid) eye drops or vehicle eye drops for 6 hours and then performed RNA sequencing on RNA extracted from whole corneas. All the animals used for this study were adrenalectomized to remove endogenous glucocorticoids. These data demonstrate that a short exposure of glucocorticoids to the cornea results in major changes in the gene expression landscape.
Published in
Glucocorticoid Receptor Signaling Is Critical for Mouse Corneal Development, Inhibition of Inflammatory Response, and Neovascularization of the Cornea
Kadmiel M, Diaz-Jimenez D, Oakley RH et al. · The American journal of pathology 2024 · PMID 39322334 · doi:10.1016/j.ajpath.2024.06.005
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Also filed as BioProject PRJNA881383 and SRA study SRP397720. Searching any of these in the dataset finder brings you back here.

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