Mitochondrial reverse electron transport in myeloid cells perpetuates neuroinflammation
RNA-seq (gene expression) · mouse · 13 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 13 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE224366_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA930730 and SRA study SRP420657. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 13 samples.
How we read this: 5 replicated groups read from 13 sample titles; they account for 13 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7021347 Peak EAE infiltrating, biol rep 1 Peak EAE infiltrating, …
- GSM7021348 Control resident, biol rep 1 Control resident, biol
- GSM7021349 Peak EAE resident, biol rep 1 Peak EAE resident, biol
- GSM7021350 Peak EAE infiltrating, biol rep 2 Peak EAE infiltrating, …
- GSM7021351 Control resident, biol rep 2 Control resident, biol
- GSM7021352 Peak EAE resident, biol rep 2 Peak EAE resident, biol
- GSM7021353 Control resident, biol rep 3 Control resident, biol
- GSM7021354 Chronic EAE resident, biol rep 1 Chronic EAE resident, b…
- GSM7021355 Chronic EAE infiltrating, biol rep 1 Chronic EAE infiltratin…
- GSM7021356 Chronic EAE resident, biol rep 2 Chronic EAE resident, b…
- GSM7021357 Chronic EAE infiltrating, biol rep 2 Chronic EAE infiltratin…
- GSM7021358 Chronic EAE resident, biol rep 3 Chronic EAE resident, b…
- GSM7021359 Chronic EAE infiltrating, biol rep 3 Chronic EAE infiltratin…
- GSE261940 Soluble ST2 induces cardiac contractile dysfunction by repressing mitochondrial electron transport chain genes in cardiomyocytes during fulminant myocarditis 20 samples shares mitochondrial, transport, electron
- GSE295742 Mitochondrial transfer to granulocytic myeloid-derived suppressor cells augments immunosuppressive activity 12 samples shares mitochondrial, myeloid
- GSE328178 Genetic suppression of myeloid receptor Clec7a attenuates microglia neuroinflammation and promotes microglial phagocytosis to delay disease progression in ALS models 14 samples shares neuroinflammation, myeloid
- GSE279388 Inactivation of Atp7b copper transporter in the intestinal epithelial cells is associated with altered lipid processing and cell growth machinery that are independent from hepatic copper accumulation and liver histology severity 76 samples shares transport
- GSE327494 Localized PD-1 CAR T therapy reprograms neuroinflammation - mouse CAR T data. 302 samples shares neuroinflammation
- GSE239814 Mitochondrial signals mediate paternal effects on offspring metabolism (Smart-Seq) 221 samples shares mitochondrial
- GSE276024 Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells [RNA-seq] 24 samples shares mitochondrial
- GSE296763 Mitochondrial respiration is necessary for CD8 T cell proliferation and cell fate 99 samples shares mitochondrial
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.